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Updated: 51 min 59 sec ago

Sirtuins and calorie restriction : Nature Reviews Molecular Cell Biology

Thu, 22/03/2012 - 22:17
Calorie restriction (CR) is by far the most robust intervention, genetic or environmental, for slowing down ageing in mammals. The identification of sirtuins as NAD-dependent protein deacetylases led to the proposal that they mediate the health benefits of CR (Guarente, 2000).